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HMMM! I do not have experience with the RF 100-400, but my wife uses the adapted EF 100-400 II on her R7 and I use the RF 100-500 on my R5. Our setup is to use at least 1/2000 shutter speed with auto ISO capped at 6400. We use AF Case 2 and ensure we have animal eye tracking turned on. My experience is that most of our friends who have image softness aren't using a fast enough SS. We also use Topaz DeNoise AI to handle any noise and occasionally use the motion blur algorithm in Topaz Sharpen AI. For the Sharpen phase I do this in a layer so I can control the output and almost always select the subject and do not apply the effect to the entire image. I am attaching an example. This was taken with the R7, Adapted EF 100-400 II at ISO 6400 and Topaz DeNoise and Topaz Sharpen AI as described above. Hope this helps.[ATTACH=full]12631[/ATTACH]